article Open AccessTop 1% cited
Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
Nature Medicine · 2008 · Vol. 14(8) · pp. 837–842
Ganesh M. Shankar✉(Harvard University)Shaomin Li(Brigham and Women's Hospital)Tapan Mehta(Harvard University)Amaya García-Muñoz(University College Dublin)Nina E. Shepardson(Brigham and Women's Hospital)Imelda M. Smith(University College Dublin)Francesca Brett(Royal College of Surgeons in Ireland)Michael A. Farrell(Beaumont Hospital)Michael J. Rowan(Trinity College Dublin)Cynthia A. Lemere(Harvard University)Ciaran M. Regan(University College Dublin)Dominic M. Walsh(University College Dublin)Bernardo L. Sabatini(Harvard University)Dennis J. Selkoe(Harvard University)
Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration MechanismsLong-term potentiationDendritic spineHippocampusSynaptic plasticityNeuroscienceAlzheimer's diseaseGlutamate receptorAmyloid (mycology)SynapseChemistry
MeSH terms
Alzheimer DiseaseAnimalsBrainHippocampusHumansLearningMemoryNeuronal PlasticityNeuronsSynapsesAmyloid beta-PeptidesDimerizationDendritic SpinesMiceRats
Citations
3,621
FWCI
131.49
field-weighted impact
References
31
Percentile
100%
vs. same field & year
Citations per year
Cited by
On the lag phase in amyloid fibril formation
Physical Chemistry Chemical Physics · 2015 · 751 citations
Alzheimer’s Disease: The Challenge of the Second Century
Science Translational Medicine · 2011 · 1,414 citations
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
Nature Reviews Drug Discovery · 2011 · 2,182 citations
The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes
Nature Neuroscience · 2012 · 1,926 citations
Defeating Alzheimer's disease and other dementias: a priority for European science and society
The Lancet Neurology · 2016 · 1,667 citations
Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage
Human Molecular Genetics · 2011 · 807 citations
Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
Journal of Clinical Investigation · 2012 · 1,804 citations
Protein Quality Control by Molecular Chaperones in Neurodegeneration
Frontiers in Neuroscience · 2017 · 333 citations
References
High-Level Neuronal Expression of Aβ<sub>1–42</sub>in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation
Journal of Neuroscience · 2000 · 1,860 citations
Natural Oligomers of the Alzheimer Amyloid-β Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway
Journal of Neuroscience · 2007 · 1,574 citations
Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
Annals of Neurology · 1991 · 4,370 citations
Amyloid plaque core protein in Alzheimer disease and Down syndrome.
Proceedings of the National Academy of Sciences · 1985 · 4,412 citations
Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease
American Journal Of Pathology · 1999 · 1,521 citations
Natural oligomers of the amyloid-β protein specifically disrupt cognitive function
Nature Neuroscience · 2004 · 1,667 citations
Soluble pool of A? amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
Annals of Neurology · 1999 · 1,797 citations
Related articles
Possible involvement of nitric oxide in long-term potentiation
European Journal of Pharmacology · 1991 · 634 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.