Pharmacokinetic screening of the phytochemicals present in Vitex negundo using Swiss ADME

Abstract

Background: It is a significant medical plant, of the Indian subcontinent and belongs to the family Lamiaceae which still requires exploring its physicochemical and, pharmacokinetic screening. Widely used in traditional medicine, Jaundice, wounds, body aches, toothaches, asthma, eye discomfort, and headaches are the main conditions that Vitex negundo is used to report. After numerous studies and researches conceal that it poses high pharmacological activities and as computational mechanics, i.e., in-silico and pharmacokinetic screening of phytoconstituents can increase among the possibilities, active compounds that show how medicinal plants work. Its common name is "Sarvaroganivarini". It has been recognized to feature some pharmacological actions such as Analgesic, Anti-inflammatory, Anti-Pyretic, Nephroprotective, Anti-Venom snake, and anti-HIV activities. Methods: The free-to-use software tool Swiss ADME, was used in the current research to evaluate the ADME properties for pharmacological and Pharmacognostic profiling of Vitex negundo. Results: Though the plant contains around 120 phytoconstituents, through the use of the software, phytoconstituents only from the root part of the plant were evaluated for their physicochemical and pharmacokinetic features. Negundin B, one of the examined constituents, exhibits favorable qualities and may be exploited in future research. The values can also be used as monographs by scientists and researchers to create potential semi- and synthetic medications for a variety of uses. Conclusion: Researchers can further investigate in vitro and in vivo studies using the findings from these investigations which reveal the pharmaceutical benefits of the traditional medicinal plant.