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Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)

Bioorganic & Medicinal Chemistry Letters · 2005 · Vol. 15(6) · pp. 1587–1590

David R. Anderson✉(Pfizer (United States))Shridhar G. Hegde✉(Pfizer (United States))Emily J. Reinhard(Pfizer (United States))Leslie Gomez(Pfizer (United States))William F. Vernier(Pfizer (United States))Len Lee(Pfizer (United States))Shuang Liu(Albany Molecular Research (United States))Aruna Sambandam(Albany Molecular Research (United States))Patricia Snider(Pfizer (United States))Liaqat Masih(Albany Molecular Research (United States))

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Melanoma and MAPK Pathways Synthesis and biological activity Cancer Mechanisms and TherapyChemistryProtein kinase AMitogen-activated protein kinaseMitogen-activated protein kinase kinasec-RafMAP2K7Cyclin-dependent kinase 2Cyclin-dependent kinase 9ASK1MAP kinase kinase kinase

MeSH terms

AnimalsHumansModels, ChemicalPyridinesStructure-Activity RelationshipTumor Necrosis Factor-alphaMolecular StructureGene ExpressionU937 CellsMAP Kinase Kinase 2Rats

Citations

265

FWCI

2.52

field-weighted impact

References

Percentile

89%

vs. same field & year

Citations per year

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