The study of transition metal (Coii, Niii, Cuii & Znii) complexes of substituted thiazole ring containing ligands and their biological activity

Abstract

A series of Schiff bases have been synthesized by reacting 4(p-flurophenyl) 2-aminothiazole and R-substituted Salicylaldehyde (R-H, 5-Me, 5-Br). The bases and their metal complexes were characterized by elemental analysis, UV-visible and Infra-red spectra, magnetic susceptibility and conductivity measurement. The Schiff base complexes act as monomeric and have octahedral in geometry. The ligand coordinated through oxygen atom of phenolic –OH group and the nitrogen atom of azomethine group. The complexes are non-electrolitic in nature.The stability constants and thermodynamic parameters (ΔH, ΔG & ΔS) were recorded. The –ve ΔG in each cases indicates the complexation is spontaneous. The enthalpy change is exothermic. The positive value of ΔS indicates the reactions are entropically favoured.The Schiff bases and their metal complexes were screened for antibacterial, antifugal and pesticidal activity.