reviewTop 1% cited
TET-mediated active DNA demethylation: mechanism, function and beyond
Nature Reviews Genetics · 2017 · Vol. 18(9) · pp. 517–534
Epigenetics and DNA MethylationGut microbiota and healthHIV Research and TreatmentDNA demethylation5-HydroxymethylcytosineBiologyDNADNA methylationCytosine5-MethylcytosineDemethylationDNA glycosylaseBase excision repair
MeSH terms
AnimalsGene Expression RegulationHumansDNA Methylation5-MethylcytosineDioxygenasesMetabolic Networks and Pathways
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References
Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers
Oncotarget · 2011 · 435 citations
Active demethylation of the paternal genome in the mouse zygote
Current Biology · 2000 · 959 citations
DNA methylation: roles in mammalian development
Nature Reviews Genetics · 2013 · 3,066 citations
DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development
Cell · 1999 · 6,039 citations
TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23)
Leukemia · 2003 · 418 citations
Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation
Cancer Cell · 2010 · 2,713 citations
TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis
Leukemia · 2009 · 418 citations
Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation
Cancer Cell · 2011 · 1,293 citations
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