article Open AccessTop 1% cited
Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation
Cancer Cell · 2010 · Vol. 18(6) · pp. 553–567
María E. Figueroa✉(Cornell University)Omar Abdel‐Wahab(Memorial Sloan Kettering Cancer Center)Chao Lü(University of Pennsylvania)Patrick S. Ward(University of Pennsylvania)Jay Patel(Memorial Sloan Kettering Cancer Center)Alan H. Shih(Memorial Sloan Kettering Cancer Center)Yushan Li(Cornell University)Neha Bhagwat(Memorial Sloan Kettering Cancer Center)Aparna Vasanthakumar(University of Chicago)Hugo F. Fernández(Moffitt Cancer Center)Martin S. Tallman(Memorial Sloan Kettering Cancer Center)Zhuoxin Sun(Dana-Farber Cancer Institute)Kristy Wolniak(Northwestern University)Justine Peeters(Erasmus MC)Wei Liu(Agios Pharmaceuticals (United States))Sung Choe(Agios Pharmaceuticals (United States))Valeria R. Fantin(Agios Pharmaceuticals (United States))Elisabeth Paietta(Montefiore Medical Center)Bob Löwenberg(Erasmus MC)Jonathan D. Licht(Northwestern University)Lucy A. Godley(University of Chicago)Ruud Delwel(Erasmus MC)Peter J.M. Valk(Erasmus MC)Craig B. Thompson(University of Pennsylvania)Ross L. Levine(Memorial Sloan Kettering Cancer Center)Ari Melnick(Cornell University)
Epigenetics and DNA MethylationAcute Myeloid Leukemia ResearchCancer-related gene regulationIDH2PhenotypeIDH1HaematopoiesisBiologyFunction (biology)Cancer researchDNA methylationMutationGenetics
MeSH terms
MDS1 and EVI1 Complex Locus ProteinCell DifferentiationDNA-Binding ProteinsHumansHydroxylationIsocitrate DehydrogenaseMutationPhenotypeProto-Oncogene ProteinsProto-OncogenesTranscription FactorsLeukemia, Myeloid, AcuteDNA MethylationMyeloid Cells5-Methylcytosine
Funding
- Howard Hughes Medical Institute
- University of Pennsylvania
- Agios Pharmaceuticals
- National Institutes of Health
- National Cancer Institute
Citations
2,713
FWCI
75.19
field-weighted impact
References
35
Percentile
100%
vs. same field & year
Citations per year
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References
The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate
Cancer Cell · 2010 · 1,966 citations
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
Nucleic Acids Research · 2002 · 13,655 citations
Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma
Cancer Cell · 2010 · 2,346 citations
Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas
Acta Neuropathologica · 2009 · 1,148 citations
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