reviewTop 1% cited
Aptamers as targeted therapeutics: current potential and challenges
Nature Reviews Drug Discovery · 2016 · Vol. 16(3) · pp. 181–202
Jiehua Zhou✉(City of Hope)John J. Rossi(City of Hope)
Advanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryBiosensors and Analytical DetectionAptamerImmunogenicityComputational biologyNucleic acidNanotechnologyBiologyAntibodyImmunologyMolecular biologyGenetics
MeSH terms
AnimalsHumansNucleic AcidsDrug Delivery SystemsRNA, Small InterferingSELEX Aptamer TechniqueAptamers, Nucleotide
Citations
2,081
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71.02
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References
212
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References
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Aptamers as therapeutics
Nature Reviews Drug Discovery · 2010 · 2,224 citations
Systematic Evolution of Ligands by Exponential Enrichment: RNA Ligands to Bacteriophage T4 DNA Polymerase
Science · 1990 · 10,260 citations
Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery
PLoS ONE · 2010 · 1,692 citations
In vitro selection of RNA molecules that bind specific ligands
Nature · 1990 · 9,645 citations
Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease
Nature Reviews Drug Discovery · 2006 · 1,556 citations
Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation
Blood · 2003 · 1,542 citations
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