review Open AccessTop 1% cited
Aptamers as therapeutics
Nature Reviews Drug Discovery · 2010 · Vol. 9(7) · pp. 537–550
Anthony D. Keefe✉(The University of Texas at Austin)Supriya Pai(The University of Texas at Austin)Andrew D. Ellington
Advanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryBacteriophages and microbial interactionsAptamerOligonucleotideNucleic acidComputational biologySmall moleculeDrug discoverySystematic evolution of ligands by exponential enrichmentChemistryBiologyBiochemistry
MeSH terms
AnimalsDNADrug Evaluation, PreclinicalGenetic TechniquesHumansLigandsNucleic Acid ConformationRNARNA, Small InterferingAptamers, NucleotideDrug Discovery
Funding
- Welch Foundation
- National Institutes of Health
- National Institute of General Medical Sciences
Citations
2,224
FWCI
36.78
field-weighted impact
References
170
Percentile
100%
vs. same field & year
Citations per year
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References
Drusen associated with aging and age‐related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease
The FASEB Journal · 2000 · 930 citations
Automated selection of anti-Protein aptamers
Bioorganic & Medicinal Chemistry · 2001 · 365 citations
Systematic Evolution of Ligands by Exponential Enrichment: RNA Ligands to Bacteriophage T4 DNA Polymerase
Science · 1990 · 10,260 citations
In vitro selection of RNA molecules that bind specific ligands
Nature · 1990 · 9,645 citations
Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease
Nature Reviews Drug Discovery · 2006 · 1,556 citations
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