article Open AccessTop 1% cited
Predicting effects of noncoding variants with deep learning–based sequence model
Nature Methods · 2015 · Vol. 12(10) · pp. 931–934
Jian Zhou✉(Princeton University)Olga G. Troyanskaya(Simons Foundation)
Genomics and Chromatin DynamicsRNA modifications and cancerRNA Research and SplicingComputational biologyChromatinBiologySequence (biology)PrioritizationExpression quantitative trait lociGeneticsDeep learningGeneSingle-nucleotide polymorphism
MeSH terms
AlgorithmsChromatinHumansModels, GeneticMutationRegulatory Sequences, Nucleic AcidTranscription FactorsGenome, HumanPolymorphism, Single NucleotideRNA, UntranslatedQuantitative Trait LociHepatocyte Nuclear Factor 3-alphaEpigenomicsSupport Vector Machine
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References
Identifying a High Fraction of the Human Genome to be under Selective Constraint Using GERP++
PLoS Computational Biology · 2010 · 1,854 citations
Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes
Genome Research · 2005 · 4,259 citations
VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencing
Genome Research · 2012 · 5,265 citations
A general framework for estimating the relative pathogenicity of human genetic variants
Nature Genetics · 2014 · 6,465 citations
Distribution and intensity of constraint in mammalian genomic sequence
Genome Research · 2005 · 1,433 citations
Detection of nonneutral substitution rates on mammalian phylogenies
Genome Research · 2009 · 2,503 citations
An integrated encyclopedia of DNA elements in the human genome
Nature · 2012 · 19,173 citations
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