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Rates of HIV‐1 Transmission per Coital Act, by Stage of HIV‐1 Infection, in Rakai, Uganda

The Journal of Infectious Diseases · 2005 · Vol. 191(9) · pp. 1403–1409

Maria J. Wawer✉(Columbia University)Ronald H. Gray(Johns Hopkins University)Nelson K. Sewankambo(MRC Epidemiology Unit)David Serwadda(Makerere University)Xianbin Li(Johns Hopkins University)Oliver Laeyendecker(Johns Hopkins University)Noah Kiwanuka(Rakai Health Sciences Program)Godfrey Kigozi(Uganda Virus Research Institute)Mohammed Kiddugavu(Uganda Virus Research Institute)Thomas Lutalo(Uganda Virus Research Institute)Fred Nalugoda(Uganda Virus Research Institute)Fred Wabwire‐Mangen(Makerere University)Mary P. Meehan(Columbia University)Thomas C. Quinn(Johns Hopkins University)

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Abstract

The rate of HIV transmission per coital act was highest during early-stage infection. This has implications for HIV prevention and for projecting the effects of antiretroviral treatment on HIV transmission.

HIV/AIDS Research and Interventions HIV Research and Treatment Adolescent Sexual and Reproductive HealthSeroconversionTransmission (telecommunications)MedicineConfidence intervalPopulationPoisson regressionCohortIndex caseImmunologyDemography

MeSH terms

Acquired Immunodeficiency SyndromeAdolescentAdultCoitusFemaleHumansMaleSexually Transmitted DiseasesTime FactorsUgandaHIV-1IncidencePoisson DistributionViral Load