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Prevention of HIV-1 Infection with Early Antiretroviral Therapy

New England Journal of Medicine · 2011 · Vol. 365(6) · pp. 493–505

Myron S. Cohen✉(University of North Carolina at Chapel Hill)Ying Qing Chen(Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa)Marybeth McCauley(Family Health International 360)Theresa GambleMina C. Hosseinipour(University of North Carolina at Chapel Hill)Nagalingeswaran Kumarasamy(Johns Hopkins University Center for AIDS Research)James Hakim(University of Zimbabwe)Johnstone KumwendaBeatriz Grinsztejn(Instituto Evandro Chagas)José Henrique Pilotto(Hospital Geral de Fortaleza)Sheela Godbole(National AIDS Research Institute)Sanjay Mehendale(National AIDS Research Institute)Suwat Chariyalertsak(Chiang Mai University)Breno Santos(Hospital Nossa Senhora da Conceição)Kenneth H. Mayer(Fenway Health)Irving Hoffman(University of North Carolina at Chapel Hill)Susan H. Eshleman(Johns Hopkins University)Estelle Piwowar‐Manning(Johns Hopkins University)Lei Wang(Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa)Joseph Makhema(Botswana Harvard AIDS Institute Partnership)Lisa Mills(Kenya Medical Research Institute)Guy de Bruyn(Perinatal HIV Research Unit)Ian SanneJoseph J. Eron(University of North Carolina at Chapel Hill)Joel E. Gallant(Johns Hopkins University)Diane V. Havlir(University of California, San Francisco)Susan Swindells(University of Nebraska Medical Center)Heather J. Ribaudo(Harvard University)Vanessa Elharrar(National Institute of Allergy and Infectious Diseases)David Burns(National Institute of Allergy and Infectious Diseases)Taha E. Taha(Johns Hopkins University)Karin Nielsen‐Saines(University of California, Los Angeles)David D. Celentano(Johns Hopkins University)Max Essex(Harvard University)Thomas R. Fleming(University of Washington)

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Abstract

The early initiation of antiretroviral therapy reduced rates of sexual transmission of HIV-1 and clinical events, indicating both personal and public health benefits from such therapy. (Funded by the National Institute of Allergy and Infectious Diseases and others; HPTN 052 ClinicalTrials.gov number, NCT00074581.).

HIV/AIDS Research and Interventions HIV Research and Treatment HIV/AIDS drug development and treatmentMedicineHazard ratioSerodiscordantConfidence intervalIncidence (geometry)Internal medicineAntiretroviral therapyTransmission (telecommunications)TuberculosisViral load

MeSH terms

AdolescentAdultDrug Therapy, CombinationFemaleHIV SeropositivityHumansMaleSexual PartnersHIV-1HIV InfectionsProportional Hazards ModelsTreatment OutcomeDisease ProgressionSpousesDisease Transmission, Infectious