articleTop 1% cited
Defining optimum lipophilicity and molecular weight ranges for drug candidates—Molecular weight dependent lower logD limits based on permeability
Bioorganic & Medicinal Chemistry Letters · 2009 · Vol. 19(10) · pp. 2844–2851
Michael J. Waring✉(AstraZeneca (United Kingdom))
Computational Drug Discovery MethodsDrug Transport and Resistance MechanismsPharmacogenetics and Drug MetabolismLipophilicityChemistryPermeability (electromagnetism)Molecular descriptorDrugQuantitative structure–activity relationshipStereochemistryPharmacologyBiochemistryMembrane
MeSH terms
AlgorithmsCell Membrane PermeabilityPharmaceutical PreparationsHumansMolecular WeightDrug DesignCaco-2 CellsHydrophobic and Hydrophilic Interactions
Citations
318
FWCI
22.37
field-weighted impact
References
30
Percentile
100%
vs. same field & year
Citations per year
Cited by
Principles and Applications of Halogen Bonding in Medicinal Chemistry and Chemical Biology
Journal of Medicinal Chemistry · 2012 · 1,272 citations
Using the Golden Triangle to optimize clearance and oral absorption
Bioorganic & Medicinal Chemistry Letters · 2009 · 368 citations
References
Applied logistic regression
Choice Reviews Online · 1990 · 35,647 citations
Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells
Biochemical and Biophysical Research Communications · 1991 · 1,852 citations
Prediction of Drug Absorption Using Multivariate Statistics
Journal of Medicinal Chemistry · 2000 · 1,889 citations
Physicochemical High Throughput Screening: Parallel Artificial Membrane Permeation Assay in the Description of Passive Absorption Processes
Journal of Medicinal Chemistry · 1998 · 1,269 citations
A Bioavailability Score
Journal of Medicinal Chemistry · 2005 · 963 citations
Physiochemical drug properties associated with in vivo toxicological outcomes
Bioorganic & Medicinal Chemistry Letters · 2008 · 954 citations
Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods
The Journal of Physical Chemistry A · 1998 · 789 citations
The influence of drug-like concepts on decision-making in medicinal chemistry
Nature Reviews Drug Discovery · 2007 · 2,269 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.