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The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study

The Lancet Oncology · 2014 · Vol. 16(1) · pp. 25–35
Richard S. FinnJohn CrownIstván LángKatalin BoérIgor BondarenkoSergey O. KulykJohannes EttlRavindranath PatelTamás PintérMarcus SchmidtYaroslav ShparykAnu ThummalaNataliya L. VoytkoCamilla FowstXin HuangSindy T. KimSophia RandolphDennis J. Slamon
Advanced Breast Cancer TherapiesBreast Cancer Treatment StudiesHER2/EGFR in Cancer ResearchPalbociclibLetrozoleMedicineOncologyBreast cancerInternal medicineClinical endpointPopulationCohortCancer

MeSH terms

LetrozoleAdministration, OralAgedAntineoplastic Combined Chemotherapy ProtocolsBreast NeoplasmsDrug Administration ScheduleEuropeFemaleHumansMiddle AgedNitrilesNorth AmericaPiperazinesPyridinesReceptors, Estrogen

Funding

  • U.S. Department of Defense
Citations
1,891
FWCI
134.48
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References
Cell cycle, CDKs and cancer: a changing paradigm
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Molecular portraits of human breast tumours
Nature · 2000 · 16,173 citations
Global cancer statistics
CA A Cancer Journal for Clinicians · 2011 · 55,006 citations
Hallmarks of Cancer: The Next Generation
Cell · 2011 · 65,668 citations
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