reviewTop 1% cited

Cell cycle, CDKs and cancer: a changing paradigm

Nature reviews. Cancer · 2009 · Vol. 9(3) · pp. 153–166

Marcos Malumbres✉(Spanish National Cancer Research Centre)Mariano Barbacid(Spanish National Cancer Research Centre)

Cancer-related Molecular Pathways Microtubule and mitosis dynamics Ubiquitin and proteasome pathwaysCyclin-dependent kinaseCell cycleCell biologyBiologyCyclin-dependent kinase 1InterphaseCell growthRestriction pointKinaseCancer research

MeSH terms

AnimalsCell CycleChromosome AberrationsDNA DamageHumansMitosisNeoplasmsNeoplastic Stem CellsCyclinsCyclin-Dependent KinasesCyclin EChromosomal InstabilityProtein Kinase InhibitorsCell ProliferationCyclin D

Citations

3,885

FWCI

77.81

field-weighted impact

References

178

Percentile

100%

vs. same field & year

Citations per year

Cited by

Cyclin-dependent kinases

Genome biology · 2014 · 1,652 citations

Cdks, cyclins and CKIs: roles beyond cell cycle regulation

Development · 2013 · 1,469 citations

Targeting Cyclin-Dependent Kinases in Human Cancers: From Small Molecules to Peptide Inhibitors

Cancers · 2015 · 340 citations

Inhibiting CDK4/6 in Breast Cancer with Palbociclib, Ribociclib, and Abemaciclib: Similarities and Differences

Drugs · 2020 · 404 citations

p21 in cancer: intricate networks and multiple activities

Nature reviews. Cancer · 2009 · 2,716 citations

The cell cycle and cancer

The Journal of Pathology · 2011 · 657 citations

The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study

The Lancet Oncology · 2014 · 1,891 citations

References

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

Genes & Development · 1994 · 1,972 citations

The spindle-assembly checkpoint in space and time

Nature Reviews Molecular Cell Biology · 2007 · 2,199 citations

Mammalian cyclin-dependent kinases

Trends in Biochemical Sciences · 2005 · 1,281 citations

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

Cell · 1997 · 5,018 citations

Functional Inactivation of the Retinoblastoma Protein Requires Sequential Modification by at Least Two Distinct Cyclin-cdk Complexes

Molecular and Cellular Biology · 1998 · 1,070 citations

D-type cyclins

Trends in Biochemical Sciences · 1995 · 983 citations

Citation Network

How this paper connects to the literature. Drag to explore, click any node to open that paper.