article Open AccessTop 1% cited
Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment
Genome biology · 2012 · Vol. 13(9) · pp. R79–R79
Xochitl C. Morgan✉(Harvard University)Timothy L. Tickle(Massachusetts Institute of Technology)Harry Sokol(Massachusetts General Hospital)Dirk Gevers(Massachusetts Institute of Technology)Kathryn L. Devaney(Massachusetts General Hospital)Doyle V. Ward(Broad Institute)Joshua A Reyes(Harvard University)Shiraz A. Shah(Hasbro Children's Hospital)Neal S. LeLeiko(Hasbro Children's Hospital)Scott B. Snapper(Harvard University)Athos Bousvaros(Brigham and Women's Hospital)Joshua R. Korzenik(Brigham and Women's Hospital)Bruce E. Sands(Icahn School of Medicine at Mount Sinai)Ramnik J. Xavier(Massachusetts General Hospital)Curtis Huttenhower(Massachusetts Institute of Technology)
Abstract
This inferred functional metagenomic information provides the first insights into community-wide microbial processes and pathways that underpin IBD pathogenesis.
Gut microbiota and healthInflammatory Bowel DiseaseHelicobacter pylori-related gastroenterology studiesBiologyMetagenomicsMicrobiomeInflammatory bowel diseaseFirmicutesUlcerative colitisHuman microbiomeDiseaseCrohn's diseaseGut flora
MeSH terms
Amino AcidsBacteriaBiological TransportHumansIntestinesPhylogenyRNA, Ribosomal, 16SInflammatory Bowel DiseasesMultivariate AnalysisLinear ModelsCase-Control StudiesSequence Analysis, DNAOxidative StressGenes, rRNACarbohydrate Metabolism
Funding
- National Science Foundation
- Crohn's and Colitis Foundation of America
- Brigham and Women's Hospital
- Massachusetts General Hospital
- Brown University
- Massachusetts Institute of Technology
- Harvard University
- Crohn's and Colitis Foundation
- Broad Institute
- Philippe Foundation
- Fondation Bettencourt Schueller
- National Institutes of Health
- Centers for Disease Control and Prevention
- Division of Biological Infrastructure
- Army Research Office
Citations
2,736
FWCI
43.63
field-weighted impact
References
108
Percentile
100%
vs. same field & year
Citations per year
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Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
Proceedings of the National Academy of Sciences · 2007 · 4,550 citations
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