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Salivary microRNA: Discovery, Characterization, and Clinical Utility for Oral Cancer Detection

Clinical Cancer Research · 2009 · Vol. 15(17) · pp. 5473–5477
Noh Jin ParkHui ZhouDavid ElashoffBradley S. HensonDragana KastratovićElliot AbemayorDavid T. Wong

Abstract

Both whole and supernatant saliva of healthy controls contained dozens of miRNAs, and similar to saliva mRNAs, these miRNAs are stable. Saliva miRNAs can be used for oral cancer detection.

MicroRNA in disease regulationCancer-related molecular mechanisms researchRNA Interference and Gene DeliverySalivamicroRNACancerTranscriptomeEndogenyBiologyBasal cellCancer researchBiomarkerMolecular biology

MeSH terms

Carcinoma, Squamous CellFemaleHumansMaleMiddle AgedMouthMouth NeoplasmsSalivaBiomarkers, TumorMicroRNAs

Funding

  • National Institutes of Health
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