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The MicroRNA Spectrum in 12 Body Fluids
Clinical Chemistry · 2010 · Vol. 56(11) · pp. 1733–1741
Jessica A. Weber(Institute for Systems Biology)David Baxter(Institute for Systems Biology)Shile Zhang(Institute for Systems Biology)David Huang(Institute for Systems Biology)Kuo‐How HuangMing‐Jen Lee(National Taiwan University)David J. Galas(Institute for Systems Biology)Kai Wang✉(Institute for Systems Biology)
Abstract
MicroRNAs are ubiquitous in all the body fluid types tested. Fluid type-specific miRNAs may have functional roles associated with the surrounding tissues. In addition, the changes in miRNA spectra observed in the urine samples from patients with different urothelial conditions demonstrates the potential for using concentrations of specific miRNAs in body fluids as biomarkers for detecting and monitoring various physiopathological conditions.
Extracellular vesicles in diseaseMicroRNA in disease regulationCancer-related molecular mechanisms researchmicroRNABody fluidSpectrum (functional analysis)Computational biologyBiologyMedicinePhysicsGeneticsInternal medicineGene
MeSH terms
Urinary Bladder NeoplasmsBody FluidsFemaleHumansKidney NeoplasmsPregnancyPregnancy TrimestersReference ValuesBiomarkersPolymerase Chain ReactionMicroRNAs
Funding
- U.S. Department of Defense
- National Institutes of Health
Citations
2,706
FWCI
32.05
field-weighted impact
References
34
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100%
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Citations per year
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References
Characterization of microRNA expression profiles in normal human tissues
BMC Genomics · 2007 · 1,022 citations
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
Nature Cell Biology · 2007 · 12,686 citations
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