review Open AccessTop 1% cited
Metformin: From Mechanisms of Action to Therapies
Cell Metabolism · 2014 · Vol. 20(6) · pp. 953–966
Marc Foretz(Délégation Paris 5)Bruno Guigas(Leiden University Medical Center)Luc Bertrand(UCLouvain)Michaël Pollak(Jewish General Hospital)Benoı̂t Viollet✉(Inserm)
Metabolism, Diabetes, and CancerPancreatic function and diabetesDiabetes Treatment and ManagementMetforminAMPKMedicineMechanism of actionDrugDiabetes mellitusType 2 diabetesPharmacologyMechanism (biology)Drug action
MeSH terms
AnimalsDiabetes Mellitus, Type 2Energy MetabolismHumansHypoglycemic AgentsMetforminOxidative PhosphorylationAMP-Activated Protein Kinases
Citations
1,443
FWCI
29.61
field-weighted impact
References
127
Percentile
100%
vs. same field & year
Citations per year
Cited by
Metformin as a Tool to Target Aging
Cell Metabolism · 2016 · 1,015 citations
References
Metformin kinetics in healthy subjects and in patients with diabetes mellitus.
British Journal of Clinical Pharmacology · 1981 · 492 citations
Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
Biochemical Journal · 2000 · 2,061 citations
Molecular mechanisms of diabetic cardiomyopathy
Diabetologia · 2014 · 878 citations
Metformin and reduced risk of cancer in diabetic patients
BMJ · 2005 · 2,356 citations
Standards of Medical Care in Diabetes
Diabetes Care · 2006 · 8,700 citations
Metformin Is an AMP Kinase–Dependent Growth Inhibitor for Breast Cancer Cells
Cancer Research · 2006 · 1,041 citations
Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis
eLife · 2014 · 1,094 citations
Role of AMP-activated protein kinase in mechanism of metformin action
Journal of Clinical Investigation · 2001 · 5,364 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.