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Inflammatory Markers and Physical Performance in Older Persons: The InCHIANTI Study
The Journals of Gerontology Series A · 2004 · Vol. 59(3) · pp. M242–M248
Matteo Cesari✉(Wake Forest University)Brenda W.J.H. Penninx(Wake Forest University)M. Pahor(Wake Forest University)Fulvio Lauretani(National Research Council)A Corsi(National Research Council)G. R. Williams(Bristol-Myers Squibb (Germany))J. M. Guralnik(National Institutes of Health)Luigi Ferrucci(National Institutes of Health)
Abstract
Inflammation, measured as high levels of IL-6, CRP, and IL-1RA, is significantly associated with poor physical performance and muscle strength in older persons. These data also support the biological face validity of physical performance measures. The assessment of inflammatory markers may represent a useful screening test and perhaps a potential target of intervention.
Adipokines, Inflammation, and Metabolic DiseasesExercise and Physiological ResponsesNutrition and Health in AgingGrip strengthMedicinePreferred walking speedPopulationPhysical therapyProspective cohort studyHand strengthDemographicsC-reactive proteinLinear regression
MeSH terms
AgedAged, 80 and overAgingFemaleHumansItalyMalePhysical FitnessProspective StudiesRisk FactorsBiomarkersInflammation Mediators
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890
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