reviewTop 10% cited
Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation
Journal of Leukocyte Biology · 2007 · Vol. 82(6) · pp. 1375–1381
Philippe Van Lint(Ghent University)Claude Libert✉(Ghent University)
Abstract
The action of matrix metalloproteinases (MMPs) was originally believed to be restricted to degradation of the extracellular matrix; however, in recent years, it has become evident that these proteases can modify many nonmatrix substrates, such as cytokines and chemokines. The use of MMP-deficient animals has revealed that these proteases can indeed influence the progression of various inflammatory processes. This review aims to provide the reader with a concise overview of these novel MMP functions in relation to leukocyte migration.
Protease and Inhibitor MechanismsCell Adhesion Molecules ResearchBlood Coagulation and Thrombosis MechanismsProteasesMatrix metalloproteinaseChemokineInflammationExtracellular matrixBiologyCytokineImmunologyCell biologyMatrix (chemical analysis)
MeSH terms
AnimalsCell MovementHumansInflammationLeukocytesProtein Processing, Post-TranslationalChemokinesMatrix Metalloproteinases
Citations
560
FWCI
9.18
field-weighted impact
References
78
Percentile
98%
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References
Chemokines
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Matrix metalloproteinases: they're not just for matrix anymore!
Current Opinion in Cell Biology · 2001 · 1,262 citations
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Genes & Development · 2000 · 1,709 citations
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Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation
Journal of Leukocyte Biology · 2007 · 560 citations
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