review Open AccessTop 1% cited
Targeting the PI3K-Akt pathway in human cancer
Cancer Cell · 2003 · Vol. 4(4) · pp. 257–262
Ji Luo(Beth Israel Deaconess Medical Center)Brendan D. Manning(Harvard University)Lewis C. Cantley✉(Beth Israel Deaconess Medical Center)
PI3K/AKT/mTOR signaling in cancerCancer-related Molecular PathwaysCRISPR and Genetic EngineeringPI3K/AKT/mTOR pathwayDNA damageCell divisionBiologySenescenceCell growthCell biologyApoptosisCancer cellProtein kinase B
MeSH terms
AnimalsCell CycleCell DivisionCell SurvivalHumansNeoplasmsNeoplasms, ExperimentalPhosphorylationProto-Oncogene ProteinsSignal TransductionProtein Serine-Threonine KinasesPhosphatidylinositol 3-KinasesModels, AnimalProtein Interaction MappingProto-Oncogene Proteins c-akt
Funding
- Howard Hughes Medical Institute
- American Cancer Society
Citations
1,282
FWCI
21.30
field-weighted impact
References
72
Percentile
100%
vs. same field & year
Citations per year
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References
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Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty
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Cellular survival: a play in three Akts
Genes & Development · 1999 · 4,218 citations
The phosphatidylinositol 3-Kinase–AKT pathway in human cancer
Nature reviews. Cancer · 2002 · 6,022 citations
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