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Mild Cognitive Impairment Can Be Distinguished From Alzheimer Disease and Normal Aging for Clinical Trials

Archives of Neurology · 2004 · Vol. 61(1) · pp. 59–59

Michael Grundman✉(University of California, San Diego)

Abstract

Patients with MCI had a predominant memory impairment with relative sparing of other cognitive domains and were intermediate between clinically normal individuals and patients with AD on cognitive and functional ratings. These results demonstrate the successful implementation of operational criteria for this unique group of at-risk patients in a multicenter clinical trial.

Dementia and Cognitive Impairment Research Alzheimer's disease research and treatments Neurological Disease Mechanisms and TreatmentsClinical Dementia RatingDementiaClinical trialMedicineDonepezilAlzheimer's diseaseMemory impairmentInternal medicineDiseaseCognitive impairment

MeSH terms

AgedAgingAlzheimer DiseaseBrainClinical Trials as TopicCognition DisordersFemaleHumansMagnetic Resonance ImagingMaleNeuropsychological TestsRisk Factors

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967

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27.29

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