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The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

Nature Cell Biology · 2010 · Vol. 12(3) · pp. 213–223

Masaaki Komatsu✉(Tokyo Metropolitan Institute of Medical Science)H. Kurokawa(Tohoku University)Satoshi Waguri(Fukushima Medical University)Keiko Taguchi(Tohoku University)Akira Kobayashi(Doshisha University)Yoshinobu Ichimura(Tokyo Metropolitan Institute of Medical Science)Yu‐shin Sou(Tokyo Metropolitan Institute of Medical Science)Izumi Ueno(Tokyo Metropolitan Institute of Medical Science)Ayako Sakamoto(Tokyo Metropolitan Institute of Medical Science)Kit I. Tong(Tohoku University)Mihee Kim(Doshisha University)Yasumasa Nishito(Tokyo Metropolitan Institute of Medical Science)Shun-ichiro Iemura(National Institute of Advanced Industrial Science and Technology)Tohru Natsume(National Institute of Advanced Industrial Science and Technology)Takashi Ueno(Juntendo University)Eiki Kominami(Juntendo University)Hozumi Motohashi(Tohoku University)Keiji Tanaka(Tokyo Metropolitan Institute of Medical Science)Masayuki Yamamoto(Tohoku University)

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Genomics, phytochemicals, and oxidative stress Epigenetics and DNA Methylation Autophagy in Disease and TherapyKEAP1AutophagyTranscription factorUbiquitin ligaseCell biologyBiologyUbiquitinTranscription (linguistics)Downregulation and upregulationCullin

MeSH terms

Autophagy-Related Protein 7Sequestosome-1 ProteinKelch-Like ECH-Associated Protein 1AnimalsAutophagyBinding, CompetitiveCalorimetryCell LineInclusion BodiesCytoskeletal ProteinsHeat-Shock ProteinsHumansLiverMice, TransgenicMicrotubule-Associated Proteins

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