article Open AccessTop 1% cited
The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level
Oncogene · 2008 · Vol. 27(25) · pp. 3576–3586
Issam Ben Sahra✉(Inserm)Kathiane Laurent(Université Côte d'Azur)Agnès Loubat(Inserm)Sophie Giorgetti‐Peraldi(Université Côte d'Azur)Pascal Colosetti(Inserm)Patrick Auberger(Université Côte d'Azur)Jean‐François Tanti(Inserm)Y. Le Marchand‐Brustel(Université Côte d'Azur)Frédéric Bost(Inserm)
Metabolism, Diabetes, and CancerCancer-related Molecular PathwaysCancer, Hypoxia, and MetabolismMetforminDU145LNCaPAMPKBiologyCyclin D1Cell growthCancer researchPharmacologyEndocrinology
MeSH terms
Antineoplastic AgentsCell SurvivalHumansHypoglycemic AgentsMaleMetforminMultienzyme ComplexesProstateProstatic NeoplasmsGene Expression Regulation, NeoplasticApoptosisProtein Serine-Threonine KinasesCyclin D1Cell Line, TumorCell Proliferation
Citations
849
FWCI
18.21
field-weighted impact
References
42
Percentile
100%
vs. same field & year
Citations per year
Cited by
Glutamine addiction: a new therapeutic target in cancer
Trends in Biochemical Sciences · 2010 · 1,747 citations
Metformin is a potent inhibitor of endometrial cancer cell proliferation—implications for a novel treatment strategy
Gynecologic Oncology · 2009 · 329 citations
Insulin and insulin-like growth factor signalling in neoplasia
Nature reviews. Cancer · 2008 · 2,013 citations
References
D-type cyclin-dependent kinase activity in mammalian cells.
Molecular and Cellular Biology · 1994 · 1,055 citations
AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
Cell Metabolism · 2005 · 2,787 citations
The retinoblastoma protein and cell cycle control
Cell · 1995 · 4,876 citations
Inhibitors of mammalian G1 cyclin-dependent kinases.
Genes & Development · 1995 · 3,256 citations
Metformin and reduced risk of cancer in diabetic patients
BMJ · 2005 · 2,356 citations
Metformin Is an AMP Kinase–Dependent Growth Inhibitor for Breast Cancer Cells
Cancer Research · 2006 · 1,041 citations
Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization
Genes & Development · 1998 · 2,108 citations
Minireview: The AMP-Activated Protein Kinase Cascade: The Key Sensor of Cellular Energy Status
Endocrinology · 2003 · 990 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.