articleTop 10% cited
Metformin is a potent inhibitor of endometrial cancer cell proliferation—implications for a novel treatment strategy
Gynecologic Oncology · 2009 · Vol. 116(1) · pp. 92–98
Leigh A. Cantrell✉(University of North Carolina at Chapel Hill)Chunxiao Zhou(University of North Carolina at Chapel Hill)Alberto A. Mendivil(University of North Carolina at Chapel Hill)Kimberly Malloy(University of North Carolina at Chapel Hill)Paola A. Gehrig(University of North Carolina at Chapel Hill)Victoria Bae‐Jump(University of North Carolina at Chapel Hill)
Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancerCancer, Hypoxia, and MetabolismMedicineMetforminEndometrial cancerOncologyCancer researchInternal medicineCell growthCancerGynecologyInsulin
MeSH terms
Cell CycleDose-Response Relationship, DrugFemaleHumansMetforminProtein KinasesRNA, MessengerSignal TransductionEndometrial NeoplasmsApoptosisTelomeraseReverse Transcriptase Polymerase Chain ReactionCell Line, TumorCell Growth ProcessesTOR Serine-Threonine Kinases
Funding
- V Foundation for Cancer Research
- National Institutes of Health
- National Center for Research Resources
Citations
329
FWCI
7.66
field-weighted impact
References
47
Percentile
98%
vs. same field & year
Citations per year
References
Endometrial cancer and obesity: Epidemiology, biomarkers, prevention and survivorship
Gynecologic Oncology · 2009 · 352 citations
Metformin and reduced risk of cancer in diabetic patients
BMJ · 2005 · 2,356 citations
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Cancer Research · 2006 · 1,041 citations
The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level
Oncogene · 2008 · 849 citations
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Science · 2009 · 15,796 citations
Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults
New England Journal of Medicine · 2003 · 7,697 citations
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