articleTop 1% cited
TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology
Nature Immunology · 2007 · Vol. 8(12) · pp. 1390–1397
Mandy J. McGeachy✉(Palo Alto University)Kristian Sass Bak‐JensenYi ChenCristina M. TatoWendy M. BlumenscheinTerrill K. McClanahanJ. Daniel
Psoriasis: Treatment and PathogenesisT-cell and B-cell ImmunologyImmunodeficiency and Autoimmune DisordersProinflammatory cytokineChemokineImmunologyCell biologyBiologyTransforming growth factorInterleukin 4Downregulation and upregulationInterleukin 10Inflammation
MeSH terms
AnimalsCell DifferentiationT-Lymphocytes, Helper-InducerT-LymphocytesInterleukin-6Transforming Growth Factor betaInterleukin-10Cell LineageInterleukin-17Mice
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References
Cutting Edge: TGF-β Induces a Regulatory Phenotype in CD4+CD25− T Cells through Foxp3 Induction and Down-Regulation of Smad7
The Journal of Immunology · 2004 · 1,114 citations
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Nature Immunology · 2005 · 4,203 citations
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
The Journal of Experimental Medicine · 2005 · 4,029 citations
IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
Nature Immunology · 2007 · 2,108 citations
TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells
Immunity · 2006 · 3,566 citations
Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation
The Journal of Experimental Medicine · 2003 · 1,633 citations
Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor <i>Foxp3 </i>
The Journal of Experimental Medicine · 2003 · 4,596 citations
Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
The Journal of Experimental Medicine · 2006 · 2,281 citations
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