articleTop 1% cited
The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt
Nature Immunology · 2008 · Vol. 9(6) · pp. 641–649
Nicolas Manel✉(New York University)Derya Unutmaz(New York University)Dan R. Littman(New York University)
Psoriasis: Treatment and PathogenesisIL-33, ST2, and ILC PathwaysImmunodeficiency and Autoimmune DisordersInterleukin 17BiologyTransforming growth factor betaTransforming growth factorCell biologyInterleukin 21IL-2 receptorInterleukin 3CytokineImmunology
MeSH terms
AnimalsCell DifferentiationHematopoietic Stem CellsHumansReceptors, Thyroid HormoneTransforming Growth Factor betaReceptors, Cytoplasmic and NuclearReceptors, Retinoic AcidInterleukin-17MiceNuclear Receptor Subfamily 1, Group F, Member 3
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References
A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12Rβ1 and a Novel Cytokine Receptor Subunit, IL-23R
The Journal of Immunology · 2002 · 1,281 citations
Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells
Nature Immunology · 2007 · 1,798 citations
IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
Nature Immunology · 2007 · 2,108 citations
T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ
Immunity · 2008 · 1,586 citations
Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium
Arthritis & Rheumatism · 1999 · 939 citations
TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology
Nature Immunology · 2007 · 1,489 citations
TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells
Immunity · 2006 · 3,566 citations
Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis
American Journal Of Pathology · 2007 · 1,168 citations
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