review Open Access
Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.
Genes & Development · 1995 · Vol. 9(22) · pp. 2723–2735
Inder M. Verma✉Jennifer K. Stevenson(Salk Institute for Biological Studies)Edward M. Schwarz(Salk Institute for Biological Studies)Daniel Van Antwerp(Cold Spring Harbor Laboratory)Shigeki Miyamoto(Salk Institute for Biological Studies)
Abstract
The growth, differentiation, and development of an organism is orchestrated by the choreographed expression of a wide array of genes. The switching "on" and "off" of gene expression is the province of transcription factors, which operate singly or in association with other proteins. Usually transcription factors form families, whereas individual members perform specific, distinct, or similar tasks. One such family includes the R ~~/ N F -K B proteins (NF-KB), which have the unique property of being sequestered in the cytoplasm in association with inhibitory proteins called IKB.
NF-κB Signaling PathwaysCytokine Signaling Pathways and InteractionsBone Metabolism and DiseasesKappaBiologyNFKB1GeneticsAssociation (psychology)Dissociation (chemistry)Molecular biologyTranscription factorGenePsychology
MeSH terms
NF-KappaB Inhibitor alphaAnimalsBase SequenceCell NucleusDNA-Binding ProteinsHumansMolecular Sequence DataOligonucleotidesPhosphorylationProto-Oncogene ProteinsTranscription FactorsSignal TransductionRetroviridae Proteins, OncogenicNF-kappa BOncogene Proteins v-rel
Funding
- American Cancer Society
- Arthritis Foundation
- George E. Hewitt Foundation for Medical Research
- Fondation pour la Recherche Médicale
- National Institutes of Health
Citations
1,725
FWCI
—
field-weighted impact
References
114
Percentile
—
vs. same field & year
Citations per year
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References
Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.
The EMBO Journal · 1991 · 3,814 citations
Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation.
Molecular and Cellular Biology · 1993 · 1,033 citations
Transcriptional regulation of endothelial cell adhesion molecules: NF‐κB and cytokine‐inducible enhancers
The FASEB Journal · 1995 · 1,723 citations
Function and Activation of NF-kappaB in the Immune System
Annual Review of Immunology · 1994 · 4,706 citations
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