reviewTop 1% cited
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
Nature Reviews Molecular Cell Biology · 2013 · Vol. 15(1) · pp. 49–63
Peter E. Czabotar✉Guillaume LessèneAndreas Strasser(Walter and Eliza Hall Institute of Medical Research)Jerry M. Adams(Walter and Eliza Hall Institute of Medical Research)
Cell death mechanisms and regulationLiver physiology and pathologyMitochondrial Function and PathologyApoptosisBcl-2 familyMitochondrionNeurodegenerationBiologyProtein familyCell biologyCancerProgrammed cell deathImmunology
MeSH terms
Amino Acid SequenceAnimalsHumansModels, MolecularMolecular Sequence DataNeoplasmsSignal TransductionApoptosisProtein Structure, SecondaryProto-Oncogene Proteins c-bcl-2Apoptosis Regulatory ProteinsProtein MultimerizationMolecular Targeted Therapy
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References
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
Cancer Cell · 2002 · 1,634 citations
The BCL-2 protein family: opposing activities that mediate cell death
Nature Reviews Molecular Cell Biology · 2007 · 4,586 citations
Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics
Developmental Cell · 2011 · 1,343 citations
PUMA, a Novel Proapoptotic Gene, Is Induced by p53
Molecular Cell · 2001 · 2,283 citations
The Combined Functions of Proapoptotic Bcl-2 Family Members Bak and Bax Are Essential for Normal Development of Multiple Tissues
Molecular Cell · 2000 · 1,468 citations
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
Cancer Cell · 2006 · 1,217 citations
The BCL-2 Family Reunion
Molecular Cell · 2010 · 1,404 citations
Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics
British Journal of Cancer · 1972 · 15,557 citations
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