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How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?

Cell Death and Differentiation · 2017 · Vol. 25(1) · pp. 104–113
Brandon J. AubreyGemma L. KellyAna JanicMarco J. HeroldAndreas Strasser
Cancer-related Molecular PathwaysCancer Research and TreatmentsCell death mechanisms and regulationBiologyProgrammed cell deathSenescenceDNA damageApoptosisCancer researchCell biologyCell cycleCell cycle checkpointDNA repair

MeSH terms

AnimalsHumansMutationNeoplasmsTranscription FactorsSignal TransductionTumor Suppressor Protein p53ApoptosisProto-Oncogene Proteins c-bcl-2Mice

Funding

  • Leukemia and Lymphoma Society
  • Australian Government
  • Medical Research Council
  • National Health and Medical Research Council
Citations
1,347
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30.97
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References
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References
Two CD95 (APO-1/Fas) signaling pathways
The EMBO Journal · 1998 · 2,997 citations
The BCL-2 protein family: opposing activities that mediate cell death
Nature Reviews Molecular Cell Biology · 2007 · 4,586 citations
PUMA, a Novel Proapoptotic Gene, Is Induced by p53
Molecular Cell · 2001 · 2,283 citations
p53 Mutations in Human Cancers
Science · 1991 · 8,098 citations
p53 in health and disease
Nature Reviews Molecular Cell Biology · 2007 · 2,221 citations
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