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Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

Molecular Cell · 2014 · Vol. 54(1) · pp. 133–146

Huayi Wang✉(National Institute of Biological Sciences, Beijing)Liming Sun(National Institute of Biological Sciences, Beijing)Lijing Su(The University of Texas Southwestern Medical Center)Josep Rizo(The University of Texas Southwestern Medical Center)Lei Liu(National Institute of Biological Sciences, Beijing)Lifeng Wang(302 Military Hospital of China)Fu‐Sheng Wang(302 Military Hospital of China)Xiaodong Wang(National Institute of Biological Sciences, Beijing)

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Cell death mechanisms and regulation Phagocytosis and Immune Regulation Endoplasmic Reticulum Stress and DiseaseBiologyKinaseCell biologyPhosphorylationCytosolNecroptosisProtein kinase domainProgrammed cell deathProtein kinase ABiochemistry

MeSH terms

Antibodies, MonoclonalBinding SitesCardiolipinsCell MembraneHeLa CellsHumansIntracellular MembranesLiverMembrane LipidsNecrosisPhosphorylationProtein ConformationProtein KinasesSubstrate SpecificityTime Factors

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Pattern Recognition Receptors and the Host Cell Death Molecular Machinery