article Open AccessTop 1% cited
Inhibition of Vascular Endothelial Growth Factor (VEGF) Signaling in Cancer Causes Loss of Endothelial Fenestrations, Regression of Tumor Vessels, and Appearance of Basement Membrane Ghosts
American Journal Of Pathology · 2004 · Vol. 165(1) · pp. 35–52
Tetsuichiro Inai(Cancer Research Institute)Michael R. Mancuso(University of California, San Francisco)Hiroya Hashizume(Niigata University)Fabienne Baffert(University of California, San Francisco)Amy Haskell(University of California, San Francisco)Peter Bałuk(University of California, San Francisco)Dana D. Hu‐Lowe(Pfizer (United States))David R. Shalinsky(Pfizer (United States))Gavin Thurston(Regeneron (United States))George D. Yancopoulos(Regeneron (United States))Donald M. McDonald✉(University of California, San Francisco)
Angiogenesis and VEGF in CancerCancer, Hypoxia, and MetabolismProtease and Inhibitor MechanismsBasement membraneVEGF receptorsVascular endothelial growth factorCancerCancer researchVascular endothelial growth factor CBasementGrowth factorVascular endothelial growth factor AInternal medicine
MeSH terms
AnimalsBasement MembraneEndothelium, VascularFluorescent DyesImmunohistochemistryLung NeoplasmsMice, Inbred C57BLMice, TransgenicMicroscopy, ElectronMicroscopy, Electron, ScanningNeoplasmsNeovascularization, PathologicSignal TransductionFluorescein-5-isothiocyanateMicroscopy, Confocal
Funding
- Pfizer
- National Institutes of Health
- University of California, San Francisco
- National Cancer Institute
Citations
757
FWCI
16.33
field-weighted impact
References
63
Percentile
100%
vs. same field & year
Citations per year
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References
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
Nature Cell Biology · 2000 · 2,775 citations
Abnormalities in Pericytes on Blood Vessels and Endothelial Sprouts in Tumors
American Journal Of Pathology · 2002 · 970 citations
The biology of VEGF and its receptors
Nature Medicine · 2003 · 9,519 citations
Openings between Defective Endothelial Cells Explain Tumor Vessel Leakiness
American Journal Of Pathology · 2000 · 1,663 citations
Endothelial-pericyte interactions in angiogenesis
Cell and Tissue Research · 2003 · 1,044 citations
Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor
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