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Estimating the rate of evolution of the rate of molecular evolution
Molecular Biology and Evolution · 1998 · Vol. 15(12) · pp. 1647–1657
Abstract
A simple model for the evolution of the rate of molecular evolution is presented. With a Bayesian approach, this model can serve as the basis for estimating dates of important evolutionary events even in the absence of the assumption of constant rates among evolutionary lineages. The method can be used in conjunction with any of the widely used models for nucleotide substitution or amino acid replacement. It is illustrated by analyzing a data set of rbcL protein sequences.
Genomics and Phylogenetic StudiesRNA and protein synthesis mechanismsGenetic diversity and population structureBiologyProtein evolutionMolecular evolutionRate of evolutionSimple (philosophy)Evolutionary biologyBayesian probabilitySubstitution (logic)Biological evolutionSet (abstract data type)
MeSH terms
AlgorithmsBiological EvolutionModels, GeneticPhylogenyPlant ProteinsPlantsRibulose-Bisphosphate CarboxylaseTimeModels, StatisticalEvolution, Molecular
Funding
- National Institutes of Health
Citations
1,341
FWCI
4.92
field-weighted impact
References
23
Percentile
96%
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Citations per year
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References
A Nonparametric Approach to Estimating Divergence Times in the Absence of Rate Constancy
Molecular Biology and Evolution · 1997 · 1,188 citations
Bayesian phylogenetic inference using DNA sequences: a Markov Chain Monte Carlo Method
Molecular Biology and Evolution · 1997 · 1,313 citations
Monte Carlo sampling methods using Markov chains and their applications
Biometrika · 1970 · 14,972 citations
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Estimating the rate of evolution of the rate of molecular evolution
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