reviewTop 1% cited
Mechanisms of Hedgehog pathway activation in cancer and implications for therapy
Trends in Pharmacological Sciences · 2009 · Vol. 30(6) · pp. 303–312
Hedgehog Signaling Pathway StudiesEpigenetics and DNA MethylationTumors and Oncological CasesParacrine signallingHedgehog signaling pathwayAutocrine signallingHedgehogCancerCancer researchBiologyStromaSignal transductionVismodegib
MeSH terms
AnilidesAnimalsAntineoplastic AgentsDrug Evaluation, PreclinicalHumansLigandsNeoplasmsPyridinesSignal TransductionHedgehog Proteins
Funding
- Genentech
Citations
644
FWCI
20.57
field-weighted impact
References
107
Percentile
100%
vs. same field & year
Citations per year
Cited by
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References
Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
Nature reviews. Cancer · 2008 · 3,448 citations
Identification of Pancreatic Cancer Stem Cells
Cancer Research · 2007 · 3,356 citations
Cyclopamine-Mediated Hedgehog Pathway Inhibition Depletes Stem-Like Cancer Cells in Glioblastoma
Stem Cells · 2007 · 598 citations
Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma
New England Journal of Medicine · 2005 · 21,276 citations
Hedgehog Signaling in Development and Cancer
Developmental Cell · 2008 · 1,075 citations
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
Genes & Development · 2002 · 1,464 citations
HEDGEHOG-GLI1 Signaling Regulates Human Glioma Growth, Cancer Stem Cell Self-Renewal, and Tumorigenicity
Current Biology · 2006 · 1,034 citations
Somatic mutations in the<i>PTCH</i>,<i>SMOH</i>,<i>SUFUH</i>and<i>TP53</i>genes in sporadic basal cell carcinomas
British Journal of Dermatology · 2005 · 396 citations
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