article Open AccessTop 1% cited
Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma
New England Journal of Medicine · 2005 · Vol. 352(10) · pp. 987–996
Roger Stupp✉(University Hospital of Lausanne)Warren Mason(Princess Margaret Hospital)Martin J. van den Bent(Erasmus MC)Michael Weller(University of Tübingen)Barbara Fisher(Western University)Martin Taphoorn(University Medical Center Utrecht)Karl Bélanger(Hôpital Notre-Dame)Alba A. BrandesChristine Marosi(Medical University of Vienna)Ulrich Bogdahn(University Hospital Regensburg)Jürgen Curschmann(University Hospital of Bern)Robert C. JanzerSamuel K. Ludwin(Queen's University)Thierry Gorlia(European Organisation for Research and Treatment of Cancer)Anouk Allgeier(European Organisation for Research and Treatment of Cancer)Denis Lacombe(European Organisation for Research and Treatment of Cancer)J. Gregory Cairncross(University of Calgary)Elizabeth A. Eisenhauer(Ontario Institute for Cancer Research)R.O. Mirimanoff(University Hospital of Lausanne)
Abstract
The addition of temozolomide to radiotherapy for newly diagnosed glioblastoma resulted in a clinically meaningful and statistically significant survival benefit with minimal additional toxicity.
Glioma Diagnosis and TreatmentBrain Metastases and TreatmentMedical Imaging Techniques and ApplicationsTemozolomideMedicineRadiation therapyConcomitantGlioblastomaAdjuvantAdjuvant radiotherapyOncologyInternal medicineSurgery
MeSH terms
TemozolomideAdrenal Cortex HormonesAdultAgedBrain NeoplasmsDacarbazineFemaleGlioblastomaHumansMaleMiddle AgedRadiotherapy, Computer-AssistedProportional Hazards ModelsSurvival AnalysisChemotherapy, Adjuvant
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