reviewTop 1% cited

NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?

Nature reviews. Immunology · 2010 · Vol. 10(3) · pp. 210–215

Jürg Tschopp✉(University of Lausanne)Kate Schroder(Monash Institute of Medical Research)

Inflammasome and immune disorders Heme Oxygenase-1 and Carbon Monoxide Neonatal Health and BiochemistryInflammasomePyrin domainCell biologyReactive oxygen speciesSecretionActivator (genetics)SignallingSignalling pathwaysChemistryCaspase 1

MeSH terms

NLR Family, Pyrin Domain-Containing 3 ProteinAnimalsAnti-Inflammatory AgentsAntigen-Antibody ComplexCarrier ProteinsHumansInflammationInterleukin-1Signal TransductionReactive Oxygen SpeciesMice, KnockoutMice

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Institute of Rheumatology Research
National Health and Medical Research Council
National Medical Research Council

Citations

1,789

FWCI

38.14

field-weighted impact

References

Percentile

100%

vs. same field & year

Citations per year

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References

Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

Cell Death and Differentiation · 2007 · 1,418 citations

Mitochondria and reactive oxygen species

Free Radical Biology and Medicine · 2009 · 1,113 citations

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

Nature Immunology · 2009 · 2,599 citations

Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor

The EMBO Journal · 2006 · 1,427 citations

The Inflammasomes: Guardians of the Body

Annual Review of Immunology · 2009 · 2,393 citations

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

Nature Immunology · 2008 · 2,375 citations