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Theoretical and Practical Approaches for Prediction of Drug–Polymer Miscibility and Solubility

Pharmaceutical Research · 2006 · Vol. 23(10) · pp. 2417–2426
Patrick J. MarsacSheri L. ShamblinLynne S. Taylor
Crystallization and Solubility StudiesDrug Solubulity and Delivery SystemsAnalytical Chemistry and ChromatographyMiscibilityMelting-point depressionThermodynamicsEntropy of fusionFlory–Huggins solution theoryHildebrand solubility parameterSolubilityPolymerDifferential scanning calorimetryCrystallization

MeSH terms

AlgorithmsCalcium Channel BlockersChemistry, PhysicalPharmaceutical PreparationsForecastingModels, ChemicalNifedipinePharmaceutic AidsPolymersPovidoneSolubilityThermodynamicsFelodipineEntropyChemical Phenomena

Funding

  • AstraZeneca
  • American Association of Colleges of Pharmacy
  • American Foundation for Pharmaceutical Education
Citations
573
FWCI
5.50
field-weighted impact
References
49
Percentile
97%
vs. same field & year
Citations per year
References
The solubility of nonelectrolytes
Journal of the Franklin Institute · 1951 · 2,338 citations
Principles of polymer chemistry
Choice Reviews Online · 1995 · 15,274 citations
Principles of polymer chemistry
Journal of Chemical Education · 1954 · 2,518 citations
Solubility parameters as predictors of miscibility in solid dispersions
Journal of Pharmaceutical Sciences · 1999 · 659 citations
Pharmaceutical Applications of Solid Dispersion Systems
Journal of Pharmaceutical Sciences · 1971 · 1,780 citations
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Theoretical and Practical Approaches for Prediction of Drug–Polymer Miscibility and Solubility · Scinovex