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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

Nature · 2012 · Vol. 483(7391) · pp. 603–607

Jordi Barretina✉(Broad Institute)Giordano CaponigroNicolas Stransky(Broad Institute)K. VenkatesanAdam A. Margolin(Broad Institute)Sung Joon Kim(Genomics Institute of the Novartis Research Foundation)Christopher J. WilsonJoseph LehárGregory V. Kryukov(Broad Institute)Dmitriy SonkinAnupama ReddyManway LiuLauren Murray(Broad Institute)Michael F. Berger(Broad Institute)John E. MonahanPaula Morais(Broad Institute)Jodi MeltzerAdam Korejwa(Broad Institute)Judit Jané‐Valbuena(Harvard University)Felipa MapaJoseph Thibault(Genomics Institute of the Novartis Research Foundation)Eva Bric-FurlongPichai RamanAaron Shipway(Genomics Institute of the Novartis Research Foundation)Ingo H. Engels(Genomics Institute of the Novartis Research Foundation)Jill Cheng(Novartis (United States))Guoying Karen Yu(Novartis (United States))Jianjun Yu(Novartis (United States))Peter AspesiMelanie de SilvaKalpana JagtapMichael D. JonesLi WangCharlie Hatton(Dana-Farber Cancer Institute)Emanuele Palescandolo(Dana-Farber Cancer Institute)Supriya Gupta(Broad Institute)Scott Mahan(Broad Institute)Carrie Sougnez(Broad Institute)Robert C. Onofrio(Broad Institute)Ted Liefeld(Broad Institute)Laura E. MacConaill(Harvard University)Wendy Winckler(Broad Institute)Michael Reich(Broad Institute)Nanxin Li(Genomics Institute of the Novartis Research Foundation)Jill P. Mesirov(Broad Institute)Stacey Gabriel(Broad Institute)Gad Getz(Broad Institute)Kristin Ardlie(Broad Institute)Vivien W. Chan(Novartis (United States))Vic E. MyerBarbara L. WeberJeff PorterMarkus WarmuthPeter M. FinanJennifer L. Harris(Genomics Institute of the Novartis Research Foundation)Matthew Meyerson(Broad Institute)Todd R. Golub(Broad Institute)Michael MorrisseyWilliam R. SellersRobert SchlegelLevi A. Garraway(Broad Institute)

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Cancer Genomics and Diagnostics Melanoma and MAPK Pathways Protein Degradation and InhibitorsCancerBiologyComputational biologyCancer researchBioinformaticsGenetics

MeSH terms

Antineoplastic AgentsChromosomes, HumanClinical Trials as TopicDrug Screening Assays, AntitumorEncyclopedias as TopicHumansModels, BiologicalNeoplasmsPharmacogeneticsPlasma CellsGenes, rasGenome, HumanGene Expression Regulation, NeoplasticDatabases, FactualSequence Analysis, DNA

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