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Butyrate Enhances Intestinal Epithelial Barrier Function via Up-Regulation of Tight Junction Protein Claudin-1 Transcription

Digestive Diseases and Sciences · 2012 · Vol. 57(12) · pp. 3126–3135

Hongbo Wang✉(Peking University First Hospital)Peng‐Yuan Wang(Peking University First Hospital)Xin Wang(Peking University)Yuan‐lian Wan(Peking University)Yucun Liu(Peking University)

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Barrier Structure and Function Studies Gut microbiota and health Digestive system and related healthClaudinTight junctionOccludinParacellular transportBarrier functionChromatin immunoprecipitationMolecular biologyCell biologyTranscription factorGene silencing

MeSH terms

Amino Acid SequenceAnimalsButyratesCell LineIntestinal MucosaPromoter Regions, GeneticProtein BindingTranscription, GeneticUp-RegulationSp1 Transcription FactorAmino Acid MotifsRNA InterferenceChromatin ImmunoprecipitationRatsClaudin-1

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Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer