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Inhibiting mitochondrial permeability transition pore opening: a new paradigm for myocardial preconditioning?
Cardiovascular Research · 2002 · Vol. 55(3) · pp. 534–543
Derek J. Hausenloy✉(University College Hospital)
Abstract
One interpretation of these data is that IPC and mitochondrial K(ATP) channel activation may protect the myocardium by inhibiting MPTP opening at reperfusion.
Cardiac Ischemia and ReperfusionFuel Cells and Related MaterialsOrgan Transplantation Techniques and OutcomesMPTPCCPAMitochondrial permeability transition poreIschemic preconditioningDiazoxideChemistryCardioprotectionPharmacologyAdenosineIschemia
MeSH terms
Mitochondrial Permeability Transition PoreAdenosineAnalysis of VarianceAnimalsAtractylosideDecanoic AcidsDiazoxideEnzyme InhibitorsHydroxy AcidsIon ChannelsMaleMitochondria, HeartPerfusionPermeabilityRandom Allocation
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