articleTop 1% cited
Subanesthetic Effects of the Noncompetitive NMDA Antagonist, Ketamine, in Humans
Archives of General Psychiatry · 1994 · Vol. 51(3) · pp. 199–199
John H. Krystal✉(Veterans Health Administration)
Abstract
These data indicate that N-methyl-D-aspartate antagonists produce a broad range of symptoms, behaviors, and cognitive deficits that resemble aspects of endogenous psychoses, particularly schizophrenia and dissociative states.
Treatment of Major DepressionTryptophan and brain disordersSchizophrenia research and treatmentDissociativePsychologyWisconsin Card Sorting TestKetamineVigilance (psychology)NMDA receptorPhencyclidineVerbal fluency testPositive and Negative Syndrome ScaleAudiology
MeSH terms
AdultBlood PressureCognitionDissociative DisordersDose-Response Relationship, DrugDouble-Blind MethodFemaleFrontal LobeHomovanillic AcidHumansHydrocortisoneKetamineMaleMethoxyhydroxyphenylglycolNeuropsychological Tests
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3,315
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107
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Subanesthetic Effects of the Noncompetitive NMDA Antagonist, Ketamine, in Humans
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