articleTop 1% cited
Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance
Nature Immunology · 2002 · Vol. 3(2) · pp. 135–142
Jun Shimizu✉(Tokyo Metropolitan Institute of Gerontology)Sayuri Yamazaki(Kyoto University)Takeshi Takahashi(Kyoto University)Yasumasa Ishida(Nara Institute of Science and Technology)Shimon Sakaguchi(Kyoto University)
T-cell and B-cell ImmunologyImmune Cell Function and InteractionImmune Response and InflammationIL-2 receptorTumor necrosis factor alphaBiologyImmunologyCytotoxic T cellCD8StimulationMonoclonal antibodyCell biologyT cell
MeSH terms
AnimalsAutoimmune DiseasesGlycoproteinsImmune ToleranceLymph NodesMice, Inbred BALB CSpleenReceptors, Interleukin-2Signal TransductionCD4-Positive T-LymphocytesCD4 AntigensT-Lymphocyte SubsetsRats, WistarReceptors, Nerve Growth FactorReceptors, Tumor Necrosis Factor
Funding
- Soochow University
Citations
1,718
FWCI
37.05
field-weighted impact
References
47
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100%
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Cited by
N<scp>aturally</scp>A<scp>rising</scp>CD4<sup>+</sup>R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>
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References
Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide
Nature Immunology · 2001 · 1,632 citations
Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells
Nature Immunology · 2010 · 5,839 citations
SRα Promoter: an Efficient and Versatile Mammalian cDNA Expression System Composed of the Simian Virus 40 Early Promoter and the R-U5 Segment of Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat
Molecular and Cellular Biology · 1988 · 1,335 citations
B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes
Immunity · 2000 · 2,031 citations
Immunologic tolerance maintained by CD25<sup>+</sup> CD4<sup>+</sup> regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance
Immunological Reviews · 2001 · 1,512 citations
CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production
The Journal of Experimental Medicine · 1998 · 2,598 citations
Induction of Tumor Immunity by Removing CD25+CD4+ T Cells: A Common Basis Between Tumor Immunity and Autoimmunity
The Journal of Immunology · 1999 · 1,473 citations
Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4
The Journal of Experimental Medicine · 2000 · 2,205 citations
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