articleTop 10% cited
Relationships between interleukin-6 activity, acute phase proteins, and function of the hypothalamic-pituitary-adrenal axis in severe depression
Psychiatry Research · 1993 · Vol. 49(1) · pp. 11–27
Michaël Maes✉Simon Scharpé(University of Antwerp)Herbert Y. Meltzer(University Hospitals of Cleveland)Eugène BosmansE. SuyJoseph R. Calabrese(University Hospitals of Cleveland)Paul Cosyns(University of Antwerp)
Stress Responses and CortisolTryptophan and brain disordersMental Health Research TopicsInternal medicineEndocrinologyDepression (economics)MelancholiaHaptoglobinAcute-phase proteinPsychologyInterleukin 6Hypothalamic–pituitary–adrenal axisMedicine
MeSH terms
Acute-Phase ProteinsAdjustment DisordersAdultAgedDepressive DisorderDexamethasoneFemaleHaptoglobinsHumansHydrocortisoneHypothalamo-Hypophyseal SystemImmune ToleranceLymphocyte ActivationMaleMiddle Aged
Citations
442
FWCI
5.75
field-weighted impact
References
97
Percentile
98%
vs. same field & year
Citations per year
Cited by
The immune-mediated alteration of serotonin and glutamate: towards an integrated view of depression
Molecular Psychiatry · 2007 · 665 citations
Stress, inflammation and cardiovascular disease
Journal of Psychosomatic Research · 2002 · 776 citations
The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine
Molecular Psychiatry · 2006 · 791 citations
Increased plasma concentrations of interleukin-6, soluble interleukin-6, soluble interleukin-2 and transferrin receptor in major depression
Journal of Affective Disorders · 1995 · 625 citations
In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice
Molecular Psychiatry · 2004 · 604 citations
CRP, IL-6 and depression: A systematic review and meta-analysis of longitudinal studies
Journal of Affective Disorders · 2013 · 943 citations
Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
Biological Psychiatry · 2001 · 1,135 citations
References
Interleukin-6 and the acute phase response
Biochemical Journal · 1990 · 2,757 citations
Stress and immunity: An integrated view of relationships between the brain and the immune system
Life Sciences · 1989 · 533 citations
Interleukin‐6 is the major regulator of acute phase protein synthesis in adult human hepatocytes
FEBS Letters · 1989 · 891 citations
A RATING SCALE FOR DEPRESSION
Journal of Neurology Neurosurgery & Psychiatry · 1960 · 32,326 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.
