article
Development of small-molecule probes that selectively kill cells induced to express mutant RAS
Bioorganic & Medicinal Chemistry Letters · 2011 · Vol. 22(4) · pp. 1822–1826
Michel Weïwer(Broad Institute)Joshua A. Bittker(Broad Institute)Timothy A. Lewis(Broad Institute)Kaoru Shimada(Howard Hughes Medical Institute)Wan Seok Yang(Columbia University)Lawrence MacPherson(Broad Institute)Sivaraman Dandapani(Broad Institute)Michelle Palmer(Broad Institute)Brent R. Stockwell(Columbia University)Stuart L. Schreiber(Broad Institute)Benito Muñoz✉(Broad Institute)
Protein Degradation and InhibitorsUbiquitin and proteasome pathwaysCancer-related Molecular PathwaysPubChemSmall moleculeOncogeneChemistryMutantCell cultureHigh-throughput screeningPhenotypic screeningChemical biologyChemical library
MeSH terms
AnimalsCell LineDrug Screening Assays, AntitumorFibroblastsHumansMutationStructure-Activity RelationshipThiophenesMolecular StructureProto-Oncogene Proteins p21(ras)ApoptosisInhibitory Concentration 50Cell Line, TumorRatsSmall Molecule Libraries
Funding
- Howard Hughes Medical Institute
- National Institutes of Health
Citations
234
FWCI
0.93
field-weighted impact
References
18
Percentile
73%
vs. same field & year
Citations per year
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References
The resurgence of covalent drugs
Nature Reviews Drug Discovery · 2011 · 1,809 citations
Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells
Cancer Cell · 2003 · 1,396 citations
<i>ras</i> GENES
Annual Review of Biochemistry · 1987 · 3,877 citations
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