article Open AccessTop 1% cited
Activation of β-catenin and Akt pathways by Twist are critical for the maintenance of EMT associated cancer stem cell-like characters
BMC Cancer · 2011 · Vol. 11(1) · pp. 49–49
Junlin Li✉(University of Kentucky)Binhua P. Zhou(University of Kentucky)
Abstract
Our results indicate that activation of β-catenin and Akt pathways are required for the sustention of EMT-associated stem cell-like traits.
Cancer Cells and MetastasisWnt/β-catenin signaling in development and cancerMetastasis and carcinoma case studiesCD44Protein kinase BCancer stem cellCancer researchEpithelial–mesenchymal transitionWnt signaling pathwayCateninStem cellBiologyTwist transcription factor
MeSH terms
Aldehyde Dehydrogenase 1 FamilyCell MovementFlow CytometryFluorescent Antibody TechniqueHeLa CellsHumansIsoenzymesNuclear ProteinsTransfectionNeoplastic Stem CellsBlotting, WesternSignal TransductionHyaluronan ReceptorsRNA InterferenceCell Line, Tumor
Funding
- Susan G. Komen
- National Institutes of Health
Citations
342
FWCI
14.64
field-weighted impact
References
35
Percentile
100%
vs. same field & year
Citations per year
References
Epithelial-Mesenchymal Transitions in Development and Disease
Cell · 2009 · 9,875 citations
Snail and Slug Mediate Radioresistance and Chemoresistance by Antagonizing p53-Mediated Apoptosis and Acquiring a Stem-Like Phenotype in Ovarian Cancer Cells
Stem Cells · 2009 · 649 citations
Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition
PLoS ONE · 2008 · 1,613 citations
Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial–mesenchymal transition
Nature Cell Biology · 2004 · 1,569 citations
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
Cell · 2008 · 8,672 citations
Identification of Pancreatic Cancer Stem Cells
Cancer Research · 2007 · 3,356 citations
Prospective identification of tumorigenic breast cancer cells
Proceedings of the National Academy of Sciences · 2003 · 10,327 citations
Tumour stem cells and drug resistance
Nature reviews. Cancer · 2005 · 3,647 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.