article Open AccessTop 1% cited
Improving the Assessment of the Outcome of Nonsynonymous SNVs with a Consensus Deleteriousness Score, Condel
The American Journal of Human Genetics · 2011 · Vol. 88(4) · pp. 440–449
Abel González-Pérez✉(Barcelona Biomedical Research Park)Núria López-Bigas(Barcelona Biomedical Research Park)
Genomics and Rare DiseasesGenomics and Phylogenetic StudiesGenomic variations and chromosomal abnormalitiesMissense mutationNonsynonymous substitutionComputer scienceMachine learningComplementarity (molecular biology)Computational biologyArtificial intelligenceMutationGenomeBiology
MeSH terms
HumansNeoplasmsSoftwareGenes, p53Consensus SequenceComputational BiologyMutation, MissensePolymorphism, Single NucleotideGenomicsDatabases, Genetic
Citations
774
FWCI
40.60
field-weighted impact
References
40
Percentile
100%
vs. same field & year
Citations per year
Cited by
Better prediction of functional effects for sequence variants
BMC Genomics · 2015 · 658 citations
Bioinformatics and Computational Tools for Next-Generation Sequencing Analysis in Clinical Genetics
Journal of Clinical Medicine · 2020 · 262 citations
Comprehensive molecular portraits of human breast tumours
Nature · 2012 · 12,217 citations
Predicting the Functional Effect of Amino Acid Substitutions and Indels
PLoS ONE · 2012 · 2,972 citations
The Phyre2 web portal for protein modeling, prediction and analysis
Nature Protocols · 2015 · 10,162 citations
Comparison and integration of deleteriousness prediction methods for nonsynonymous SNVs in whole exome sequencing studies
Human Molecular Genetics · 2014 · 1,162 citations
A general framework for estimating the relative pathogenicity of human genetic variants
Nature Genetics · 2014 · 6,465 citations
PredictSNP: Robust and Accurate Consensus Classifier for Prediction of Disease-Related Mutations
PLoS Computational Biology · 2014 · 864 citations
References
Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm
Nature Protocols · 2009 · 6,687 citations
A method and server for predicting damaging missense mutations
Nature Methods · 2010 · 13,461 citations
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
Nucleic Acids Research · 1994 · 64,626 citations
EnsemblCompara GeneTrees: Complete, duplication-aware phylogenetic trees in vertebrates
Genome Research · 2008 · 1,324 citations
ProbCons: Probabilistic consistency-based multiple sequence alignment
Genome Research · 2005 · 1,133 citations
SIFT: predicting amino acid changes that affect protein function
Nucleic Acids Research · 2003 · 6,783 citations
Distribution and intensity of constraint in mammalian genomic sequence
Genome Research · 2005 · 1,433 citations
Predicting Deleterious Amino Acid Substitutions
Genome Research · 2001 · 2,698 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.