reviewTop 1% cited

The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes

Toxicology and Applied Pharmacology · 2004 · Vol. 199(3) · pp. 193–209

A. Parkinson✉(Sekisui XenoTech (United States))

Pharmacogenetics and Drug Metabolism Drug Transport and Resistance Mechanisms Drug-Induced Hepatotoxicity and ProtectionMicrosomeCYP3A4CYP1A2Internal medicineEndocrinologyCytochrome P450HepatocyteCYP2B6BiologyCirrhosis

MeSH terms

AgingAlcohol DrinkingAnimalsCells, CulturedCytochrome P-450 Enzyme SystemEnzyme InductionEthnicityFemaleHumansIsoenzymesLiver CirrhosisMaleMicrosomes, LiverSex CharacteristicsSmoking

Citations

380

FWCI

15.51

field-weighted impact

References

Percentile

99%

vs. same field & year

Citations per year

Cited by

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Sex Differences in the Expression of Hepatic Drug Metabolizing Enzymes

Molecular Pharmacology · 2009 · 807 citations

References

Casarett and Doull's Toxicology: The Basic Science of Poisons

Annals of Internal Medicine · 1992 · 3,307 citations

Gender Effects in Pharmacokinetics and Pharmacodynamics

Drugs · 1995 · 502 citations

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

Journal of Pharmacology and Experimental Therapeutics · 1994 · 2,779 citations

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