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The Study on Cognition and Prognosis in the Elderly (SCOPE)

Journal of Hypertension · 2003 · Vol. 21(5) · pp. 875–886

Hans Lithell✉(Uppsala University)Lennart HanssonIngmar Skoog(University of Gothenburg)Dag Elmfeldt(AstraZeneca (Sweden))Albert HofmanBertil Olofsson(AstraZeneca (Sweden))Peter Trenkwalder(Ludwig-Maximilians-Universität München)Alberto Zanchetti(IRCCS Istituto Auxologico Italiano)

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Abstract

In elderly hypertensive patients, a slightly more effective blood pressure reduction during candesartan-based therapy, compared with control therapy, was associated with a modest, statistically non-significant, reduction in major cardiovascular events and with a marked reduction in non-fatal stroke. Cognitive function was well maintained in both treatment groups in the presence of substantial blood pressure reductions. Both treatment regimens were generally well tolerated.

Blood Pressure and Hypertension Studies Dementia and Cognitive Impairment Research Sodium Intake and HealthMedicineCandesartanBlood pressureInternal medicineCardiologyMyocardial infarctionStroke (engine)DementiaCognitive declinePrehypertension

MeSH terms

AgedAged, 80 and overAntihypertensive AgentsBenzimidazolesBiphenyl CompoundsBlood PressureCardiovascular DiseasesCognitionDementiaDose-Response Relationship, DrugDouble-Blind MethodEuropeFemaleFollow-Up StudiesHelsinki Declaration