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Blood pressure-dependent and independent effects of agents that inhibit the renin–angiotensin system

Journal of Hypertension · 2007 · Vol. 25(5) · pp. 951–958

Blood Pressure Lowering Treatment Trialists' Collaboration✉(The George Institute for Global Health)

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Abstract

There are similar blood pressure-dependent effects of ACEI and ARB for the risks of stroke, CHD and heart failure. For ACEI, but not ARB, there is evidence of blood pressure-independent effects on the risk of major coronary disease events.

Blood Pressure and Hypertension Studies Renin-Angiotensin System Studies Heart Failure Treatment and ManagementMedicineBlood pressureStroke (engine)Internal medicineCardiologyHeart failureAngiotensin-converting enzymeConfidence intervalPlaceboACE inhibitor

MeSH terms

Angiotensin-Converting Enzyme InhibitorsBlood PressureCardiovascular DiseasesHumansRenin-Angiotensin SystemSensitivity and SpecificityRandomized Controlled Trials as TopicAngiotensin II Type 1 Receptor Blockers

Citations

411

FWCI

29.38

field-weighted impact

References

43

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100%

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Citations per year

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References

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New England Journal of Medicine · 2000 · 8,641 citations

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Journal of Hypertension · 2003 · 1,408 citations

Effects of aggressive blood pressure control in normotensive type 2 diabetic patients on albuminuria, retinopathy and strokes

Kidney International · 2002 · 849 citations

Effects of Losartan on Renal and Cardiovascular Outcomes in Patients with Type 2 Diabetes and Nephropathy

New England Journal of Medicine · 2001 · 7,433 citations

Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol

The Lancet · 2002 · 5,407 citations

Major Outcomes in High-Risk Hypertensive Patients Randomized to Angiotensin-Converting Enzyme Inhibitor or Calcium Channel Blocker vs Diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)

JAMA · 2002 · 5,671 citations

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