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ER stress (PERK/eIF2α phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation

Cell Death and Differentiation · 2006 · Vol. 14(2) · pp. 230–239
Yoriko KourokuEriko FujitaIsei TanidaTakashi UenoAtsushi IsoaiHiroshi KumagaiSatoshi OgawaRandal J. KaufmanEiki KominamiTakashi Momoi
Autophagy in Disease and TherapyEndoplasmic Reticulum Stress and DiseaseGenetic Neurodegenerative DiseasesAutophagyUnfolded protein responseATG5Cell biologyEndoplasmic reticulumProgrammed cell deathATG12PhosphorylationChemistryBiology

MeSH terms

Autophagy-Related Protein 5AdenineAnimalsAutophagyEndoplasmic ReticulumEnzyme ActivationGene Expression RegulationLeucineLysosomesMicrotubule-Associated ProteinsModels, BiologicalPepstatinsPeptidesPhosphorylationRNA, Messenger

Funding

  • York University
  • National Institutes of Health
  • School of Medicine, New York University
  • Japan Society for the Promotion of Science
Citations
912
FWCI
18.80
field-weighted impact
References
51
Percentile
100%
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Citations per year
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